Oral squamous cell carcinoma during long-term treatment with hydroxyurea.
Clin Exp Dermatol
; 29(6): 605-7, 2004 Nov.
Article
en En
| MEDLINE
| ID: mdl-15550132
ABSTRACT
Hydroxyurea (HU) is commonly used for the treatment of chronic myelogenous leukaemia, polycythemia vera and essential thrombocythaemia. Patients receiving HU present a number of side-effects including skin/mucosa changes and tumours. Mucocutaneous abnormalities include xerosis, ichthyosiform lesions, dark brown pigmentation of skin folds and nails, malleolar ulcers, oral mucositis and oral ulcers. Cutaneous squamous/basal cell carcinomas have also often been reported following long-term administration of HU. HU-induced carcinogenesis is due to both the mutagenic potential of this agent and to an impairment of DNA repair mechanisms after damage by external factors such as ultraviolet radiation. Oral cancer following long-term treatment with HU has been reported only once, in a patient with concomitant multiple skin tumours. We present the unique case of a patient with polycythemia vera who developed oral cancer after 15 years of HU therapy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Policitemia Vera
/
Neoplasias de la Lengua
/
Carcinoma de Células Escamosas
/
Inhibidores de la Síntesis del Ácido Nucleico
/
Hidroxiurea
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Clin Exp Dermatol
Año:
2004
Tipo del documento:
Article
País de afiliación:
Italia