Apoptosis in yeast.
Curr Opin Microbiol
; 7(6): 655-60, 2004 Dec.
Article
en En
| MEDLINE
| ID: mdl-15556039
ABSTRACT
Apoptosis is a highly regulated cellular suicide program crucial for metazoan development. However, dysfunction of apoptosis also leads to several diseases. Yeast undergoes apoptosis after application of acetic acid, sugar- or salt-stress, plant antifungal peptides, or hydrogen peroxide. Oxygen radicals seem to be key elements of apoptotic execution, conserved during evolution. Furthermore, several yeast orthologues of central metazoan apoptotic regulators have been identified, such as a caspase and a caspase-regulating serine protease. In addition, physiological occurrence of cell death has been detected during aging and mating in yeast. The finding of apoptosis in yeast, other fungi and parasites is not only of great medical relevance but will also help to understand some of the still unknown molecular mechanisms at the core of apoptotic execution.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Regulación Fúngica de la Expresión Génica
/
Apoptosis
/
Hongos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Microbiol
Asunto de la revista:
MICROBIOLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Alemania