Orexin stimulates breathing via medullary and spinal pathways.
J Appl Physiol (1985)
; 98(4): 1387-95, 2005 Apr.
Article
en En
| MEDLINE
| ID: mdl-15557013
ABSTRACT
A central neuronal network that regulates respiration may include hypothalamic neurons that produce orexin, a peptide that influences sleep and arousal. In these experiments, we investigated 1) projections of orexin-containing neurons to the pre-Botzinger region of the rostral ventrolateral medulla that regulates rhythmic breathing and to phrenic motoneurons that innervate the diaphragm; 2) the presence of orexin A receptors in the pre-Botzinger region and in phrenic motoneurons; and 3) physiological effects of orexin administered into the pre-Botzinger region and phrenic nuclei at the C3-C4 levels. We found orexin-containing fibers within the pre-Botzinger complex. However, only 0.5% of orexin-containing neurons projected to the pre-Botzinger region, whereas 2.9% of orexin-containing neurons innervated the phrenic nucleus. Neurons of the pre-Botzinger region and phrenic nucleus stained for orexin receptors, and activation of orexin receptors by microperfusion of orexin in either site produced a dose-dependent, significant (P <0.05) increase in diaphragm electromyographic activity. These data indicate that orexin regulates respiratory activity and may have a role in the pathophysiology of sleep-related respiratory disorders.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nervio Frénico
/
Respiración
/
Médula Espinal
/
Neuropéptidos
/
Bulbo Raquídeo
/
Receptores de Neuropéptido
/
Péptidos y Proteínas de Señalización Intracelular
/
Neuronas Motoras
/
Vías Nerviosas
Límite:
Animals
Idioma:
En
Revista:
J Appl Physiol (1985)
Asunto de la revista:
FISIOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos