Exercise tolerance and daily life in McArdle's disease.
Muscle Nerve
; 31(5): 637-41, 2005 May.
Article
en En
| MEDLINE
| ID: mdl-15614801
ABSTRACT
McArdle's disease is a common disorder of muscle metabolism and is due to myophosphorylase deficiency. The major complaint of patients with this disease is effort intolerance. Although the clinical features of affected patients are well known, their daily lifestyle is not well documented. The main objective of this work was to assess their mean daily energy expenditure (DEE) and compare it with control subjects. Thirty patients and 87 control subjects completed a questionnaire. A 3-day self-record of daily physical activities was used to estimate the mean DEE for patients and control subjects. A separate section of the questionnaire was used to assess patients' clinical features and daily lifestyle. The DEE of patients (44.1 +/- 6.9 kcal/kg) was not significantly different from control subjects (44.5 +/- 5.6 kcal/kg). Half of the patients with McArdle's disease performed a daily physical leisure activity as sport, sometimes at a high level (17%). Despite large individual variation, physical abilities and patients' symptoms were negatively correlated. Physical leisure activity significantly decreased the sensation of muscle pain (P < 0.03). These findings show that patients with McArdle's disease do not have a strictly sedentary lifestyle. Moreover, physical exercise appears to have positive effects on the main clinical features, such as effort intolerance. Thus, regular, moderate physical activity may be beneficial in McArdle's disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Actividades Cotidianas
/
Enfermedad del Almacenamiento de Glucógeno Tipo V
/
Tolerancia al Ejercicio
/
Músculo Esquelético
/
Debilidad Muscular
/
Metabolismo Energético
Tipo de estudio:
Etiology_studies
/
Qualitative_research
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Muscle Nerve
Año:
2005
Tipo del documento:
Article
País de afiliación:
Francia