Apoptosis phenomenon in the selected neoplasms of the glial origin.
Rocz Akad Med Bialymst
; 49 Suppl 1: 16-8, 2004.
Article
en En
| MEDLINE
| ID: mdl-15638361
ABSTRACT
Gliomas cause a therapeutic problem because of their localization and asymptomatic growth in the initial phase. Neoplastic growth is connected with disturbance between proliferation and apoptosis. In the study, we assessed the Bcl-2 family proteins involved in apoptosis in gliomas. The study comprised 61 patients with gliomas and based on tissue material sent for the diagnosis. Apoptosis was assessed in various types of gliomas and was defined by the apoptotic index (IA) and shown immunohistochemically with using Bcl-2, Bax and Bcl-x antibodies. The data were statistically analyzed. We found an increased percentage of the Bax (+) cells in less matured gliomas. A reverse dependence was revealed for Bcl-x. It was found that, probably in gliomas, the assessment of the Bcl-2 family proteins may serve only as an additional parameter for the evaluation of the disease course and the therapeutic success.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligodendroglioma
/
Astrocitoma
/
Neoplasias Encefálicas
/
Apoptosis
/
Glioblastoma
Límite:
Humans
Idioma:
En
Revista:
Rocz Akad Med Bialymst
Asunto de la revista:
MEDICINA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Polonia