Honokiol induces apoptosis via cytochrome c release and caspase activation in activated rat hepatic stellate cells in vitro.
Planta Med
; 71(1): 82-4, 2005 Jan.
Article
en En
| MEDLINE
| ID: mdl-15678380
ABSTRACT
The therapeutic goal in liver fibrosis is the reversal of fibrosis and the selective clearance of activated hepatic stellate cells (HSCs) by inducing apoptosis. Over the past several years, we have screened for natural products that mediate apoptosis in activated HSCs. Among the candidate compounds, honokiol, isolated from Magnoliae cortex, was found to induce apoptotic death in activated rat HSCs, while there was no cell viability change in hepatocytes, at concentrations of 12.5-50 microM. Apoptosis was identified by DNA fragmentation, activation of caspase-3 and -9, and the proteolytic cleavage of poly(ADP-ribose) polymerase, down-regulation of bcl-2 and the release of mitochondrial cytochrome c into the cytoplasm.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos de Bifenilo
/
Medicamentos Herbarios Chinos
/
Apoptosis
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Lignanos
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Magnolia
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Fitoterapia
/
Antineoplásicos Fitogénicos
Límite:
Animals
Idioma:
En
Revista:
Planta Med
Año:
2005
Tipo del documento:
Article
Pais de publicación:
ALEMANHA
/
ALEMANIA
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DE
/
DEUSTCHLAND
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GERMANY