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Clinical outcome of immunonutrition in a heterogeneous intensive care population.
Kieft, Hans; Roos, Arnout N; van Drunen, Jenneke D E; Bindels, Alexander J G H; Bindels, Jacques G; Hofman, Zandrie.
Afiliación
  • Kieft H; Department of Intensive Care, Isala Clinics (Location Sophia), Dr. van Heesweg 2, 8025 AB Zwolle, The Netherlands. h.kieft@isala.nl
Intensive Care Med ; 31(4): 524-32, 2005 Apr.
Article en En | MEDLINE | ID: mdl-15703894
ABSTRACT

OBJECTIVE:

To study the effect of a high-protein enteral formula enriched with arginine, glutamine, and antioxidants and containing omega3 fatty acids and a mixture of fibers, on the clinical outcome of a heterogeneous intensive care (ICU) population. DESIGN AND

SETTING:

A randomized, prospective, double blind, controlled, two-center clinical trial in two intensive care units in The Netherlands. PATIENTS AND

PARTICIPANTS:

A total of 597 adult ICU patients expected to require enteral tube feeding for more than 2 days were randomized to receive immunonutrition or an isocaloric control formula.

INTERVENTIONS:

Patients received either the immunonutrition or the control feed. MEASUREMENTS AND

RESULTS:

Intention-to-treat and per-protocol analyses showed no statistically significant difference in clinical outcome parameters between the two groups. Results of the intention-to-treat analysis in control vs. immunonutrition were median ICU length of stay in days, 8.0 (IQR 5.0-16.0) vs. 7.0 (4.0-14.0); median hospital length of stay in days, 20.0 (IQR 10.0-34.0) vs. 20.0 (10.0-35.0); median days of ventilation, 6.0 (IQR 3.0-12.0) vs. 6.0 (IQR 3.0-12.0); ICU mortality, 26.8% vs. 28.2%; in-hospital mortality, 36.4% vs. 38.5%; infectious complications, 41.7% vs. 43.0%.

CONCLUSIONS:

The results of this largest randomized, controlled trial found that in the general ICU population immunonutrition has no beneficial effect on clinical outcome parameters. These results are consistent with the literature that is currently available.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resultado del Tratamiento / Nutrición Enteral / Cuidados Críticos / Inmunoterapia Tipo de estudio: Clinical_trials / Guideline Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Intensive Care Med Año: 2005 Tipo del documento: Article País de afiliación: Países Bajos
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resultado del Tratamiento / Nutrición Enteral / Cuidados Críticos / Inmunoterapia Tipo de estudio: Clinical_trials / Guideline Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Intensive Care Med Año: 2005 Tipo del documento: Article País de afiliación: Países Bajos