Neuropsychiatric porphyria in patients with refractory epilepsy: report of three cases.
J Neurol Neurosurg Psychiatry
; 76(3): 380-3, 2005 Mar.
Article
en En
| MEDLINE
| ID: mdl-15716531
ABSTRACT
OBJECTIVES:
Although epileptic seizures are an infrequent feature of acute attacks of the neuropsychiatric porphyrias, there are no significant reports of porphyria in chronic epilepsy. This paper attempts to redress the balance.METHODS:
Three case reports, including detailed laboratory and molecular diagnostics.RESULTS:
Two patients with variegate porphyria and one with acute intermittent porphyria, referred within 1 year to a specialist porphyria service, with a long history of chronic refractory epileptic seizures, are described.CONCLUSIONS:
Porphyria may be an aetiological factor in some cases of chronic refractory partial or generalised epilepsy. Porphyria should also be considered if addition of a new anti-epileptic medication causes a major deterioration in the epilepsy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Porfirias
/
Epilepsia
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Neurol Neurosurg Psychiatry
Año:
2005
Tipo del documento:
Article
País de afiliación:
Reino Unido