Neuroendocrine (HPA axis) and clinical correlates during fluvoxamine and amitriptyline treatment.
Psychiatry Res
; 133(2-3): 281-4, 2005 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-15741004
ABSTRACT
The effect of amitriptyline on hypothalamic-pituitary-adrenocortical (HPA) axis activity was compared with that of fluvoxamine in 38 patients suffering from DMS-IV major depressive disorder. Basal plasma adrenocorticotropic hormone and cortisol levels were determined in the so-called "observation window" of an hour (0800-0900 h), and cortisol levels were determined again at 2000 h. Clinical and biochemical assessments were performed before therapy (T0), at day 14 (T14), and at day 42 (T42) of the course of antidepressant treatment. At T0, neuroendocrine parameters did not differ in patients from those in controls, except for the ratio between cortisol levels at 2000 h and the mean level of the "window" (ratio F20/F8), which was significantly higher, suggesting a dysregulation of the circadian pattern of cortisol. Although a decrease in the ratio F20/F8 was already apparent at T14 of both treatments, the repeated measures analysis of variance failed to demonstrate a significant variation with time (T0, T14, and T42) and with treatment (amitriptyline and fluvoxamine) for any hormonal measure. At T42, both treated groups showed a similar level of clinical improvement. Our results did not demonstrate any effect of antidepressant therapy on the cortisol circadian rhythm abnormality.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sistema Hipófiso-Suprarrenal
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Esquizofrenia
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Fluvoxamina
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Inhibidores Selectivos de la Recaptación de Serotonina
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Trastorno Depresivo Mayor
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Amitriptilina
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Sistema Hipotálamo-Hipofisario
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Psychiatry Res
Año:
2005
Tipo del documento:
Article
País de afiliación:
Italia