[Changes in content of inflammatory cytokines and troponin I in peri-operative periods of coronary artery bypass grafting with or without cardiopulmonary bypass].

ABSTRACT

OBJECTIVE: To evaluate the effects of coronary artery bypass grafting (CABG) with or without cardiopulmonary bypass (CPB) on inflammatory response and myocardial injury. METHODS: Sixty patients undergoing elective CABG were randomly divided into CABG with CPB group (CCABG, 30 cases) and CABG without CPB group (OPCABG, 30 cases). Blood samples were collected from central vein to assay interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), MB isoenzyme of creatine kinase (CK-MB) and troponin I (cTnI) before operation and 2, 8, 24, as well as 48 hours after operation, and all clinical data of the patients were recorded accordingly. RESULTS: After operation, the contents of IL-6, IL-8, TNF-alpha, CK-MB and cTnI were significantly higher in CCABG group than those before operation and those in OPCABG group, while most of these parameters showed little change in OPCABG group both in operative or postoperative period. CONCLUSION: The results suggest that OPCABG may provide better myocardial protection and less systemic inflammatory response than CCABG.