Chromosome 7 abnormalities in acute megakaryoblastic leukemia associated with Down syndrome.
Cancer Genet Cytogenet
; 158(2): 184-7, 2005 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-15796967
ABSTRACT
A 2-year-old girl with Down syndrome (DS) developed acute megakaryoblastic leukemia (AMKL) following a transient myeloproliferative disorder (TMD). The blast cells showed an altered karyotype of 47,XX,r(7),+21c. Serial cytogenetic studies during the course of the illness showed rapid stepwise clonal chromosome changes, including a ring chromosome 7, associated with treatment refractoriness. We reviewed 10 published cases of Down syndrome-related AMKL (DS-AMKL) showing chromosome 7 abnormalities and found that these changes do not carry the same prognostic weight as for non-DS children. For DS-AMKL, therefore, other prognostic factors besides clonal cytogenetic changes need to be identified for planning optimal therapy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cromosomas Humanos Par 7
/
Leucemia Megacarioblástica Aguda
/
Aberraciones Cromosómicas
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Síndrome de Down
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Trastornos de los Cromosomas
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Child, preschool
/
Female
/
Humans
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
2005
Tipo del documento:
Article