[The value of gene expression profiles using micoarrays for the individualisation of adjuvant therapy after surgery for breast cancer]. / De waarde van genexpressieprofielen vastgesteld met microarrays voor het individualiseren van adjuvante therapie bij patiënten na chirurgische behandeling wegens mammacarcinoom.
Ned Tijdschr Geneeskd
; 149(12): 618-22, 2005 Mar 19.
Article
en Nl
| MEDLINE
| ID: mdl-15813427
ABSTRACT
Gene-expression profiles are a promising development in determining the prognosis of patients with primary breast cancer. They accurately assess the risk on distant recurrence of disease and show if the patient might benefit from adjuvant therapy after surgery thus minimising the risk of distant metastases. Three clinically relevant profiles on prognosis have now been published, two of which come from the Netherlands, and whose results are an improvement on those using traditional clinical parameters i.e. the St. Gallen and the National Institutes of Health criteria. These gene-expression profiles mean that 25-40% of patients need no longer undergo adjuvant systemic therapy (chemotherapy and/or endocrine therapy). Although the risk-stratifying power of these profiles has been established, their power in predicting the response of the patients to adjuvant systemic therapy still awaits scientific proof.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Análisis de Secuencia por Matrices de Oligonucleótidos
/
Perfilación de la Expresión Génica
/
Antineoplásicos
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
Idioma:
Nl
Revista:
Ned Tijdschr Geneeskd
Año:
2005
Tipo del documento:
Article