Vitamin C supplementation to prevent premature rupture of the chorioamniotic membranes: a randomized trial.
Am J Clin Nutr
; 81(4): 859-63, 2005 Apr.
Article
en En
| MEDLINE
| ID: mdl-15817864
ABSTRACT
BACKGROUND:
Vitamin C is involved in the synthesis and degradation of collagen and is important for maintenance of the chorioamniotic membranes. Inadequate availability of ascorbic acid during pregnancy has been proposed as a risk factor for premature rupture of the chorioamniotic membranes (PROM).OBJECTIVE:
The objective of the study was to evaluate the effectiveness of 100 mg vitamin C/d in preventing PROM.DESIGN:
A controlled double-blind trial was performed. Pregnant women (n = 126) in their 20th wk of gestation were invited; 120 accepted and were randomly assigned to 2 groups (100 mg vitamin C/d or placebo). Every 4 wk, plasma and leukocyte vitamin C concentrations were measured, and each subject was evaluated for cervicovaginal infection. The incidence of PROM was recorded for each group as an indicator of the protective effect of vitamin C supplementation.RESULTS:
One hundred nine patients finished the study. Mean plasma vitamin C concentrations decreased significantly throughout the pregnancy in both groups (P = 0.001), and there were no significant differences between groups. Between weeks 20 and 36, mean leukocyte vitamin C concentrations decreased from 17.5 to 15.23 microg/10(8) cells in the placebo group and increased from 17.26 to 22.17 microg/10(8) cells in the supplemented group (within- and between-group differences P = 0.001). The incidence of PROM was 14 per 57 pregnancies (24.5%) in the placebo group and 4 per 52 pregnancies (7.69%) in the supplemented group (relative risk 0.26; 95% CI 0.078, 0.837).CONCLUSION:
Daily supplementation with 100 mg vitamin C after 20 wk of gestation effectively lessens the incidence of PROM.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácido Ascórbico
/
Rotura Prematura de Membranas Fetales
/
Antioxidantes
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Región como asunto:
Mexico
Idioma:
En
Revista:
Am J Clin Nutr
Año:
2005
Tipo del documento:
Article
País de afiliación:
México