Endometrial oxytocin receptor concentration and activity in prepubertal ewe lambs.
Reprod Domest Anim
; 40(2): 123-5, 2005 Apr.
Article
en En
| MEDLINE
| ID: mdl-15819960
ABSTRACT
We have measured endometrial oxytocin receptor concentrations during prepuberty in ewe lambs, and have investigated the effect of progesterone on the activity of these receptors. In the first study, oxytocin receptor concentrations were undetectable in 2-week prenatal lambs but had increased immediately following birth and were then maintained throughout prepubertal life. Despite the presence of oxytocin receptors animals showed no prostaglandin F(2alpha) (PGF(2alpha)) release in response to exogenous oxytocin challenge at either 3 or 5 months of age. In a second study in 4-month-old ewe lambs treatment with exogenous progesterone resulted in the appearance of PGF(2alpha) release in response to oxytocin after 10 days of treatment. Thus, during the prepubertal life, ewe lambs possess the prerequisites of a luteolytic mechanism in that they have a dormant population of oxytocin receptors in which progesterone can induce oxytocin-stimulated PGF(2alpha) release.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Progesterona
/
Oxitocina
/
Ovinos
/
Dinoprost
/
Receptores de Oxitocina
/
Endometrio
Límite:
Animals
Idioma:
En
Revista:
Reprod Domest Anim
Asunto de la revista:
MEDICINA REPRODUTIVA
/
MEDICINA VETERINARIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Reino Unido