Natural killer cell alloreactivity for leukemia therapy.
J Immunother
; 28(3): 175-82, 2005.
Article
en En
| MEDLINE
| ID: mdl-15838373
ABSTRACT
Donor-versus-recipient natural killer (NK) cell alloreactivity derives from a mismatch between donor NK clones, carrying specific inhibitory receptors for self MHC class I molecules, and MHC class I ligands on recipient cells. When faced with mismatched allogeneic targets, these donor NK clones sense the missing expression of self HLA class I alleles and mediate alloreactions. Transplantation from NK alloreactive haploidentical donors controls acute myeloid leukemia relapse and improves engraftment without causing graft-versus-host disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Asesinas Naturales
/
Leucemia
/
Trasplante de Células Madre Hematopoyéticas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Immunother
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
NEOPLASIAS
/
TERAPEUTICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Italia