Granulysin induces cell death with nuclear accumulation.
J Med Dent Sci
; 52(1): 1-7, 2005 Mar.
Article
en En
| MEDLINE
| ID: mdl-15868735
ABSTRACT
Exogenously added granulysin was reported to kill mammalian target cells. The sites of actions and molecular mechanisms of granulysin in target cell killing, however, are presently unclear. We here examine the effects of granulysin with the target HeLa cells transiently expressed with GFP-fused 9 kDa granulysin. Endogenously expressed GFP-fused granulysin was preferentially localized in the nucleus and induced apoptotic cell death accompanying with phosphatidylserine translocation and nuclear condensation in a caspase-independent manner. These results suggest that granulysin enters the nucleus of target cells and induces apoptosis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos de Diferenciación de Linfocitos T
/
Apoptosis
Límite:
Humans
Idioma:
En
Revista:
J Med Dent Sci
Asunto de la revista:
MEDICINA
/
ODONTOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Japón