Syntheses of chlorogenin 6alpha-O-acyl-3-O-beta-chacotriosides and their antitumor activities.

Zhang, Yichun; Li, Yingxia; Guo, Tiantian; Guan, Huashi; Shi, Jiwei; Yu, Qiang; Yu, Biao

Zhang, Yichun; Li, Yingxia; Guo, Tiantian; Guan, Huashi; Shi, Jiwei; Yu, Qiang; Yu, Biao.

Afiliación

Zhang Y; Key Laboratory of Marine Drugs, Ministry of Education, Marine Drug and Food Institute, Ocean University of China, Qingdao.

Carbohydr Res ; 340(8): 1453-9, 2005 Jun 13.

Article en En | MEDLINE | ID: mdl-15882851

ABSTRACT

ABSTRACT

Chlorogenin 3-O-beta-chacotrioside (1) and its 6alpha-O-acyl derivatives (2-6) were concisely synthesized. Introduction of a hydroxyl or acyloxy group onto the C-6 of the steroidal aglycone of dioscin decreased significantly the cytotoxicity of the parent saponin (dioscin).

Asunto(s)

Antineoplásicos/síntesis química; Antineoplásicos/farmacología; Saponinas/síntesis química; Saponinas/farmacología; Antineoplásicos/química; Células HeLa; Humanos; Concentración 50 Inhibidora; Datos de Secuencia Molecular; Estructura Molecular; Saponinas/química

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saponinas / Antineoplásicos Límite: Humans Idioma: En Revista: Carbohydr Res Año: 2005 Tipo del documento: Article

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