The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: antagonists versus agonists.
Bioorg Med Chem Lett
; 15(12): 3020-3, 2005 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-15908209
ABSTRACT
Structure-activity relationship study of bipiperidine amide 1 has identified the reverse bipiperidine amide 4a as a CC chemokine-3 (CCR3) receptor antagonist. Optimization of the structure-activity relationship of compound 4a has resulted in the identification of a CCR3 antagonist 4i as well as a CCR3 agonist 13.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piperidinas
/
Receptores de Quimiocina
/
Amidas
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos