[Effect of diphenylhydantoin administered during gestation and lactation on the motor development and cerebellar histology of the young rat]. / Action de la diphénylhydantoïne administrée pendant la gestation et l'allaitement, sur le développement moteur et l'histologie du cervelet du jeune rat.
C R Seances Soc Biol Fil
; 172(6): 1057-62, 1978.
Article
en Fr
| MEDLINE
| ID: mdl-159092
ABSTRACT
Rattus norvegicus females were treated by diphenylhydantoin (D.P.H.), all along pregnancy and lactation. 4 groups were constituted a 100 mg DPH/kg/day group, a 50 mg DPH/kg/day group; a placebo group (treated with pure water), and control group. D.P.H. was given twice a day by a gastric tube. The cerebellar Purkinje cells studied through light microscopy and transmission electron microscopy in young rats (25 days old) showed no visible alteration. 2 motorcoordination tests were applied to the young rats, during their 2nd and 3rd weeks of post-natal life. Young rats of DPH 100, DPH 50 and placebo groups showed a backwardness relatively to control. This backwardness may be attributed to the maternal forced feeding stress, but not to a specific action of the DPH.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenitoína
/
Cerebelo
/
Destreza Motora
Límite:
Animals
/
Pregnancy
Idioma:
Fr
Revista:
C R Seances Soc Biol Fil
Año:
1978
Tipo del documento:
Article