A genetic interpretation of the variation in inbreeding depression.
Genetics
; 170(3): 1373-84, 2005 Jul.
Article
en En
| MEDLINE
| ID: mdl-15911591
ABSTRACT
Inbreeding depression is expected to play an important but complicated role in evolution. If we are to understand the evolution of inbreeding depression (i.e., purging), we need quantitative genetic interpretations of its variation. We introduce an experimental design in which sires are mated to multiple dams, some of which are unrelated to the sire but others are genetically related owing to an arbitrary number of prior generations of selfing or sib-mating. In this way we introduce the concept of "inbreeding depression effect variance," a parameter more relevant to selection and the purging of inbreeding depression than previous measures. We develop an approach for interpreting the genetic basis of the variation in inbreeding depression by (1) predicting the variation in inbreeding depression given arbitrary initial genetic variance and (2) estimating genetic variance components given half-sib covariances estimated by our experimental design. As quantitative predictions of selection depend upon understanding genetic variation, our approach reveals the important difference between how inbreeding depression is measured experimentally and how it is viewed by selection.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Selección Genética
/
Evolución Molecular
/
Endogamia
/
Modelos Genéticos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Genetics
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos