Selective inhibition of Trypanosoma cruzi GAPDH by "bi-substrate" analogues.
Org Biomol Chem
; 3(11): 2070-2, 2005 Jun 07.
Article
en En
| MEDLINE
| ID: mdl-15917890
ABSTRACT
A new series of "bi-substrate" analogues have been synthesized as potential inhibitors of the glyceraldehyde-3-phosphate dehydrogenase and one lead compound has been identified that inhibits the enzyme from Trypanosoma cruzi with good affinity and very high (50-fold) specificity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trypanosoma cruzi
/
Inhibidores Enzimáticos
/
Gliceraldehído-3-Fosfato Deshidrogenasas
Límite:
Animals
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM