Effect of chemical enhancers on the in vitro percutaneous absorption of sumatriptan succinate.
Eur J Pharm Biopharm
; 61(1-2): 50-5, 2005 Sep.
Article
en En
| MEDLINE
| ID: mdl-15925502
ABSTRACT
The effects of percutaneous enhancers on the transdermal absorption of sumatriptan succinate were investigated by in vitro permeation studies. Pretreatment of porcine skin with ethanol (vehicle), polyethylene glycol 600, Span 20, oleic acid, R-(+)-limonene, alpha-bisabolol and 1,8-cineole (at 5% in ethanol, w/w) produced in all cases an increase in the flux of sumatriptan. The amount of sumatriptan retained in the skin was also determined. Ethanol has showed a low but significant increment on the drug transdermal flux. Treatment of the skin with alpha-bisabolol shows the same enhancer effect than ethanol. Span 20, oleic acid, and polyethylene glycol 600 have shown a moderate enhancing activity on transdermal flux of sumatriptan. R-(+)-limonene showed the greatest ability to enhance the flux of sumatriptan.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Absorción Cutánea
/
Solventes
/
Sumatriptán
Límite:
Animals
Idioma:
En
Revista:
Eur J Pharm Biopharm
Asunto de la revista:
FARMACIA
/
FARMACOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
España