Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study.

Karamohamed, Samer; Golbe, L I; Mark, M H; Lazzarini, A M; Suchowersky, O; Labelle, N; Guttman, Mark; Currie, L J; Wooten, G F; Stacy, M; Saint-Hilaire, M; Feldman, R G; Liu, J; Shoemaker, C M; Wilk, J B; DeStefano, A L; Latourelle, J C; Xu, G; Watts, R; Growdon, J; Lew, M; Waters, C; Vieregge, P; Pramstaller, P P; Klein, C; Racette, B A; Perlmutter, J S; Parsian, A; Singer, Carlos; Montgomery, E; Baker, K; Gusella, J F; Herbert, A; Myers, R H

Karamohamed, Samer; Golbe, L I; Mark, M H; Lazzarini, A M; Suchowersky, O; Labelle, N; Guttman, Mark; Currie, L J; Wooten, G F; Stacy, M; Saint-Hilaire, M; Feldman, R G; Liu, J; Shoemaker, C M; Wilk, J B; DeStefano, A L; Latourelle, J C; Xu, G; Watts, R; Growdon, J; Lew, M; Waters, C; Vieregge, P; Pramstaller, P P; Klein, C; Racette, B A; Perlmutter, J S; Parsian, A; Singer, Carlos; Montgomery, E; Baker, K; Gusella, J F; Herbert, A; Myers, R H.

Afiliación

Karamohamed S; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA. samer@bu.edu

Mov Disord ; 20(9): 1188-91, 2005 Sep.

Article en En | MEDLINE | ID: mdl-15966003

ABSTRACT

ABSTRACT

Parkinson's disease (PD) is a neurodegenerative disorder in which relatives of the probands are affected approximately 4 times as frequently as relatives of control subjects. Several genes have been implicated as genetic risk factors for PD. We investigated the presence of six reported genetic variations in the SCNA, NR4A2, and DJ-1 genes in 292 cases of familial Parkinson's disease from the GenePD study. None of the variants were found in the GenePD families. Our results suggest that other variants or genes account for the familial risk of PD within the GenePD study.

Asunto(s)

Proteínas de Unión al ADN/genética; Proteínas Oncogénicas/genética; Enfermedad de Parkinson/genética; Factores de Transcripción/genética; alfa-Sinucleína/genética; Anciano; Eliminación de Gen; Predisposición Genética a la Enfermedad; Variación Genética/genética; Genotipo; Humanos; Péptidos y Proteínas de Señalización Intracelular; Persona de Mediana Edad; Miembro 2 del Grupo A de la Subfamilia 4 de Receptores Nucleares; Mutación Puntual/genética; Reacción en Cadena de la Polimerasa; Proteína Desglicasa DJ-1; Factores de Riesgo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Factores de Transcripción / Proteínas Oncogénicas / Proteínas de Unión al ADN / Alfa-Sinucleína Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Aged / Humans / Middle aged Idioma: En Revista: Mov Disord Asunto de la revista: NEUROLOGIA Año: 2005 Tipo del documento: Article País de afiliación: Estados Unidos

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