Identification of a novel HLA-DRB1 allele (HLA-DRB1*111902*).
Tissue Antigens
; 66(1): 67-8, 2005 Jul.
Article
en En
| MEDLINE
| ID: mdl-15982264
ABSTRACT
In this paper, we report a new HLA-DRB1 allele identified in a male acute myeloid leukaemia Chinese patient. This sample was initially typed as DRB1*11XX using commercial polymerase chain reaction-sequence-specific primers kit. When it was typed using a chip-based sequence-specific oligonucleotide technique, a novel hybridization pattern that does not match any known alleles was observed. Through sequencing, we have identified this allele as a new HLA-DRB1 allele, which was later named HLA-DRB1*111902 by the WHO Nomenclature Committee. The sequence of this new allele differs from DRB1*111901 by one nucleotide (from G to C) at 203nt of exon 2 but does not cause any amino acid substitution.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucemia Mieloide Aguda
/
Antígenos HLA-DR
/
Alelos
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Tissue Antigens
Año:
2005
Tipo del documento:
Article