[Mechanisms of epigenetic reprogramming in Mammalian resonstructed embryos produced by nuclear transfer.].
Yi Chuan
; 27(3): 473-80, 2005 May.
Article
en Zh
| MEDLINE
| ID: mdl-15985417
ABSTRACT
Circumstantial studies indicated that incomplete or inappropriate epigenetic reprogramming of donor nuclei was likely to be the primary reason for failures in nuclear transfer. In this view, we discussed the roles of several epigenetic mechanisms, including DNA methylation, chromatin remodeling, imprinting and X chromosome inactivation, telomere maintenance, and epigenetic inheritance in the observed abnormalities in clones from different species. Understanding the mechanisms underlying epigenetic reprogramming control will help us resolve the inherent problems in nuclear transfer technology and make its applications promising.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Embrión de Mamíferos
/
Técnicas de Transferencia Nuclear
Límite:
Animals
Idioma:
Zh
Revista:
Yi Chuan
Asunto de la revista:
GENETICA
Año:
2005
Tipo del documento:
Article