A phase I trial of celecoxib in combination with docetaxel and irinotecan in patients with advanced cancer.
Cancer Chemother Pharmacol
; 56(6): 623-8, 2005 Dec.
Article
en En
| MEDLINE
| ID: mdl-15999272
ABSTRACT
PURPOSE:
This phase I study was conducted to determine the safety, tolerability and maximum tolerated dose of the combination of celecoxib, a selective cyclooxygenase-2 inhibitor, with docetaxel and irinotecan, in patients with advanced solid tumors. PATIENTS ANDMETHODS:
Patients with solid tumors received one of three escalating dose levels of daily celecoxib in combination with docetaxel and irinotecan administered on days 1 and 8 of an every 21-day cycle. Toxicities were graded by the National Cancer Institute Common Toxicity Criteria (NCI CTC) and recorded as maximum grade per patient for each treatment cycle.RESULTS:
A total of 19 patients received 90 cycles of treatment through three dose levels. Dose-limiting toxicities were nausea and diarrhea. The most common treatment-related toxicities in all cycles of treatment were alopecia, fatigue, diarrhea, nausea, vomiting, anemia, anorexia, and edema.. The maximum tolerated dose was established at celecoxib 400 mg twice a day continuously, weekly docetaxel 30 mg/m2 and irinotecan 50 mg/m2 for 2 weeks every 21 days. Disease stabilization (five or more cycles) was documented in eight patients.CONCLUSION:
The combination of celecoxib with docetaxel and irinotecan did not ameliorate irinotecan-induced diarrhea. Although prolonged disease stabilization was achieved in some patients, we do not recommend combining celecoxib with docetaxel and irinotecan because of lack of activity and the side effect profile of this combination.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pirazoles
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Sulfonamidas
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Camptotecina
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Protocolos de Quimioterapia Combinada Antineoplásica
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Inhibidores de la Ciclooxigenasa
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Taxoides
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Neoplasias
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Antineoplásicos Fitogénicos
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Cancer Chemother Pharmacol
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos