Pericentric inversion of chromosome 12; a three family study.
Hum Genet
; 89(3): 292-4, 1992 May.
Article
en En
| MEDLINE
| ID: mdl-1601419
ABSTRACT
A pericentric inversion of chromosome 12 has been followed in three large independently ascertained Danish families. Out of a total number of 52 persons examined, 25 were found to carry the inversion. The breakpoints in all three families were localized to p13 and q13, resulting in more than one-third of the total length of the chromosomes being inverted. However, no chromosomal aberrations arising because of meiotic crossing-over inside the inverted area have been found among the offspring of the carriers. The percentage of spontaneous abortions among carriers is found to be high, viz. 33%. The segregation rate is calculated to be 0.58, which is not significantly different from an expected segregation rate of 0.5. In family 3, an additional inversion of a chromosome 9 has been found in 4 individuals. Our results are discussed in relation to previous findings and with respect to the genetic counselling of families with pericentric inversions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cromosomas Humanos Par 12
/
Aborto Espontáneo
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Inversión Cromosómica
Límite:
Female
/
Humans
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Male
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Pregnancy
Idioma:
En
Revista:
Hum Genet
Año:
1992
Tipo del documento:
Article
País de afiliación:
Dinamarca