Neuroprotective activity of proproten in rats with experimental local photothrombosis of the prefrontal cortex.

Romanova, G A; Voronina, T A; Dugina, Yu L; Martyushev-Poklad, A V; Sergeeva, S A; Epstein, O I; Barskov, I V

Romanova, G A; Voronina, T A; Dugina, Yu L; Martyushev-Poklad, A V; Sergeeva, S A; Epstein, O I; Barskov, I V.

Afiliación

Romanova GA; Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Russia.

Bull Exp Biol Med ; 139(4): 404-7, 2005 Apr.

Article en En | MEDLINE | ID: mdl-16027865

ABSTRACT

ABSTRACT

Proproten (ultralow doses of antibodies to S100 protein) exhibited neuroprotective activity in rats with experimental photochemical thrombosis of the prefrontal cortex. Proproten was more potent than standard neuroprotectors piracetam and vinpocetine in alleviating the signs of memory disorders produced by ischemic injury. Pathomorphological study of the damaged area confirmed the neuroprotective effect of Proproten.

Asunto(s)

Anticuerpos/farmacología; Fármacos Neuroprotectores/farmacología; Corteza Prefrontal/patología; Proteínas S100/inmunología; Trombosis/prevención & control; Animales; Masculino; Fotoquímica; Ratas; Ratas Wistar

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Proteínas S100 / Corteza Prefrontal / Fármacos Neuroprotectores / Anticuerpos Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2005 Tipo del documento: Article País de afiliación: Rusia

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