Increased phosphorylation and decreased level of IkappaBalpha during aging in rat liver.
Biogerontology
; 6(2): 141-5, 2005.
Article
en En
| MEDLINE
| ID: mdl-16034681
ABSTRACT
Nuclear factor kappa B (NFkappaB) is an evolutionary conserved transcription factor, which coordinates various metabolic processes triggered by innate and adaptive immune responses. Supakar et al. (J. Biol. Chem. 270 837-842, 1995) had reported a 10-fold increase in DNA binding activity of NFkappaB in liver of old rats. In this study, we have analyzed the changes in the level of NFkappaB, inhibitor of NFkappaB (IkappaBalpha), phosphorylated-IkappaBalpha (p-IkappaBalpha) and IkappaB kinase (IKK) in rat liver during aging by reverse transcription polymerase chain reaction and/or western blotting. Here we demonstrate that there is an age-dependent increase in the level of p-IkappaBalpha with concomitant decrease in the level of IkappaBalpha, which may be correlated with increased inflammation, oxidative stress and higher level of activated NFkappaB in rat liver in old age.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
FN-kappa B
/
Proteínas I-kappa B
/
Hígado
Límite:
Animals
Idioma:
En
Revista:
Biogerontology
Asunto de la revista:
GERIATRIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
India