Pneumococcal meningitis and etanercept--chance or association?
J Infect
; 51(2): E49-51, 2005 Aug.
Article
en En
| MEDLINE
| ID: mdl-16038750
Rheumatoid arthritis is a severe deforming chronic disease which has major implications for mortality and quality of life. Agents with anti-tumour necrosis factor alpha (TNFalpha) activity are a new modality of therapy, which can significantly reduce the acute inflammation in this condition. However, TNFalpha is a cytokine involved in initiating the protective immune response; consequently, patients receiving this therapy are at increased risk of infection. Etanercept is a recombinant form of the p75 TNF receptor (TNF-RII) dimerised by fusion with a portion of the human IgG1 Fc tail with anti-TNFalpha activity. We report the first case of a patient with rheumatoid arthritis who developed pneumococcal meningitis whilst on etanercept, suggesting a possible association between etanercept and this severe life threatening infection.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Otitis Media
/
Streptococcus pneumoniae
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Inmunoglobulina G
/
Antirreumáticos
/
Inmunosupresores
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Meningitis Neumocócica
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Aspecto:
Patient_preference
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Infect
Año:
2005
Tipo del documento:
Article
Pais de publicación:
Reino Unido