Anti-phospholipid antibodies in serum from patients with Guillain-Barré syndrome.
Intensive Care Med
; 31(10): 1401-8, 2005 Oct.
Article
en En
| MEDLINE
| ID: mdl-16044250
ABSTRACT
OBJECTIVE:
The Guillain-Barré syndrome (GBS) is an acute inflammatory polyneuropathy related to autoimmunity. However, no conclusive etiological concept has yet been found. We examined the variation in autoantibodies to lipids in serum of GBS patients in response to the course of the disease but investigated titer modifications during treatment with gamma-globulin. DESIGN ANDSETTING:
Prospective clinical study in a 14-bed general ICU. PATIENTS Nine patients with GBS and nine controls were included in the study. MEASUREMENTS ANDRESULTS:
Four blood samples were obtained before and after treatment. Serum samples, diluted 160, were tested by enzyme-linked immunosorbent assay for IgM, IgA, and IgG antibodies to phosphatidylcholine, phosphatidylinositol, cardiolipin, phosphatidic acid, phosphatidylserine, phosphatidylglycerol, phosphatidylethanolamine, sphingomyelin, and gangliosides. Anti-phospholipid antibodies of the IgM, IgA, and IgG families were detected in all GBS patients but in none of the controls. Phosphatidylinositol, cardiolipin, phosphatidylcholine, and phosphatidic acid were the main antigens. All patients developed anti-phosphatidylinositol antibodies of the IgM family and anti-cardiolipin antibodies of the IgA and IgG families. A decrease in the level of anti-phospholipid autoantibodies was observed after 1 day of treatment with gamma-globulin. Two days after ending gamma-globulin administration the IgG antibodies increased again.CONCLUSIONS:
Our findings suggest that in GBS there is an extensive immune reaction, which is altered after gamma-globulin treatment. Anti-cardiolipin and anti-phosphatidylinositol antibodies could be useful markers for the response to treatment.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Gammaglobulinas
/
Anticuerpos Antifosfolípidos
/
Síndrome de Guillain-Barré
Tipo de estudio:
Observational_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Intensive Care Med
Año:
2005
Tipo del documento:
Article
País de afiliación:
Grecia