Childhood overweight and maturational timing in the development of adult overweight and fatness: the Newton Girls Study and its follow-up.
Pediatrics
; 116(3): 620-7, 2005 Sep.
Article
en En
| MEDLINE
| ID: mdl-16099850
ABSTRACT
OBJECTIVE:
Although several studies have suggested that early menarche is associated with the development of adult overweight, few have accounted for childhood overweight before menarche. STUDYDESIGN:
A 30-year follow-up of the original participants in the Newton Girls Study, a prospective study of development in a cohort of girls followed through menarche, provided data on premenarcheal relative weight and overweight (BMI >85th percentile), prospectively obtained age at menarche, self-reported adult BMI, overweight (BMI > 25), obesity (BMI > 30) and, for a subset of participants, percentage body fat by dual-energy x-ray absorptiometry.RESULTS:
Of the 448 women who participated in the adult follow-up at a mean age of 42.1 years (SD 0.76 years), 307 had childhood data with which to characterize premenarcheal and menarcheal weight status and age at menarche. After a follow-up of 30.1 years (SD 1.4 years), reported BMI was 23.4 (4.8), 28% were overweight, and 9% were obese. In multivariate linear and logistic-regression analyses, almost all of the influence on adult weight status was a result of premenarcheal weight status (model R2 = 0.199). Inclusion of a variable to reflect menarcheal timing provided very little additional information (model R2 = 0.208). Girls who were overweight before menarche were 7.7 times more likely to be overweight as adults (95% confidence interval 2.3, 25.8), whereas early menarche (at < or = 12 years of age) did not elevate risk (odds ratio 1.3, 95% confidence interval 0.66, 2.43). A similar pattern of results was observed when percentage body fat in adulthood was evaluated.CONCLUSIONS:
The apparent influence of early maturation on adult female overweight is largely a result of the influence of elevated relative weight on early maturation. Interventions to prevent and treat overweight should focus on girls before they begin puberty.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Desarrollo Sexual
/
Sobrepeso
/
Obesidad
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Child
/
Female
/
Humans
Idioma:
En
Revista:
Pediatrics
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos