Shedding of membrane vesicles by tumor and endothelial cells.
Ital J Anat Embryol
; 110(2 Suppl 1): 127-33, 2005.
Article
en En
| MEDLINE
| ID: mdl-16101030
ABSTRACT
Shedding of membrane vesicles is a vital phenomenon frequently observed in tumor cells and suggested to be involved in several aspects of tumor progression. Our previous studies have shown that human breast tumor cells rapidly shed membrane vesicles containing matrix metalloproteinases (MMPs). In this study we present that human umbilical vein endothelial cells (HUVEC) as well as different tumor cell lines (human ovarian cancer, CABA I and A2780, and hepatocarcinoma cell line, SK-Hep 1) shed vesicles in the extracellular medium. These vesicles carry MMPs and their inhibitors TIMPs. We conclude that tumor and endothelial cells shed MMP-containing vesicles and this may represent a mechanism for regulating focalized proteolytic activity and a way to interact with microenvironment during tumor angiogenesis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Membrana Celular
/
Vesículas Secretoras
/
Células Endoteliales
/
Invasividad Neoplásica
/
Neoplasias
/
Neovascularización Patológica
Límite:
Female
/
Humans
Idioma:
En
Revista:
Ital J Anat Embryol
Asunto de la revista:
ANATOMIA
/
EMBRIOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Italia