Molecular study of the hematopoietic zinc finger gene in three unrelated families with gray platelet syndrome.
J Thromb Haemost
; 3(9): 2077-80, 2005 Sep.
Article
en En
| MEDLINE
| ID: mdl-16102114
Hematopoietic zinc finger (HZF) null mice have features reminiscent of patients with gray platelet syndrome (GPS), a rare inherited bleeding disorder. This similarity has suggested that HZF deregulation might be involved in the human disease. The sequence of the eight exons of the HZF gene as well as the study of its expression in blood samples from five patients belonging to three different families did not reveal any modifications when compared with healthy donors. This study indicates that HZF is unlikely to be responsible for GPS.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos de las Plaquetas Sanguíneas
Tipo de estudio:
Observational_studies
Límite:
Humans
Idioma:
En
Revista:
J Thromb Haemost
Asunto de la revista:
HEMATOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Reino Unido