Fluorescent anion sensor derived from cholic acid: the use of flexible side chain.
J Org Chem
; 70(19): 7640-6, 2005 Sep 16.
Article
en En
| MEDLINE
| ID: mdl-16149794
ABSTRACT
[structure see text] The fluorescent photoinduced electron transfer (PET) chemosensors 1-3 were synthesized from cholic acid. 1 and 2 containing amidothiourea groups as anion receptive sites demonstrated much higher affinity toward anions than 3 containing traditional thiourea H-bond donating group. Comparative studies on their binding affinity toward carboxylates, dihydrogen phosphate, and halides revealed that the amidothiourea moiety on the C17 side chain could work cooperatively with H-bond donating groups on C7 and C12 to bind spherical halogen anions. An unexpected specific fluorescence enhancement of 1 by coordinating bromide ion was observed.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Técnicas Biosensibles
/
Ácidos Cólicos
/
Aniones
Idioma:
En
Revista:
J Org Chem
Año:
2005
Tipo del documento:
Article