Circadian rhythms in Neurospora crassa: clock gene homologues in fungi.
Fungal Genet Biol
; 42(11): 887-92, 2005 Nov.
Article
en En
| MEDLINE
| ID: mdl-16154782
ABSTRACT
Computer-based analysis of a total of 17 filamentous fungal and yeasts genomes has shown (1) homologues of frq, wc-1, wc-2, and vvd, key gene components of the Neurospora crassa clock, are present in Magnaporthe grisea, Gibberella zeae, and Podospora anserina, suggesting an frq-based oscillator in these organisms; (2) some fungal species that are more distantly related to Neurospora, such as Rhizopus oryzae do not appear to have frq homologues; (3) many fungal species that do not appear to contain frq, such as Aspergillus nidulans, do contain wc homologues; (4) of 11 well-described genes classified as clock-controlled genes (ccgs), in Neurospora, all of them were found to have homologues in other fungi; (5) the ccg-8 gene of N. crassa has homologies to opi1p, a transcriptional regulatory gene in Saccharomyces cerevisiae involved in inositol regulation. This suggests the possibilities of rhythmic inositol regulation, and/or a cascade of rhythmic activation of other genes in N. crassa.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Relojes Biológicos
/
Ritmo Circadiano
/
Biología Computacional
/
Neurospora crassa
Idioma:
En
Revista:
Fungal Genet Biol
Asunto de la revista:
GENETICA
/
MICROBIOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos