Metabolism of (-)-6(S)-hydroxy-4(R)-(1-hydroxy-1-methylethyl)-1- cyclohexene-1-ethanol in rat and dog.
Xenobiotica
; 22(1): 41-9, 1992 Jan.
Article
en En
| MEDLINE
| ID: mdl-1615706
ABSTRACT
1. The metabolism of a new mucoactive drug, chemically (-)-6(S)-hydroxy-4(R)- (1-hydroxy-1-methylethyl)-1-cyclohexene-1-ethanol (CO/1408), has been studied in rat and dog after a single oral dose; eight metabolites were identified. 2. Oxidation of the primary and secondary alcohol groups, hydroxylation in allylic positions and conjugation with glucuronic acid occurred in both species. Products of oxidation on the double bond have not been identified. 3. Using reversed-phase h.p.l.c. and beta-cyclodextrin in the eluent it was found that the glucuronide metabolites varied with species and with the biological fluid examined.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ciclohexanoles
Límite:
Animals
Idioma:
En
Revista:
Xenobiotica
Año:
1992
Tipo del documento:
Article
País de afiliación:
Italia