Serum VEGF and b-FGF profiles after tension-free or conventional hernioplasty.
Langenbecks Arch Surg
; 390(6): 528-33, 2005 Nov.
Article
en En
| MEDLINE
| ID: mdl-16180047
ABSTRACT
BACKGROUND:
Angiogenesis is strongly influenced by vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF), whose production is also regulated by interferon (IFN)-gamma and interleukin (IL)-10. The aim of this study was to evaluate the modifications of serum VEGF, b-FGF, IFN-gamma and IL-10 levels in patients with inguinal hernia undergoing hernioplasty with the Lichtenstein technique (LH) using polypropylene mesh or with Bassini open conventional inguinal hernia repair (BH). MATERIALS ANDMETHODS:
Randomly, 16 patients underwent BH, and 16 were treated with the LH technique using polypropylene mesh. Blood samples were collected 24 h prior to surgery and then 6, 24, 48 and 168 h postoperatively. The serum concentrations of VEGF, b-FGF, IFN-gamma and IL-10 were evaluated.RESULTS:
In BH patients, a peak of VEGF synthesis at 6 h with a normalization of this parameter 24 h after surgery has been observed. In the same subjects, b-FGF synthesis increased after surgery reaching significant levels 48 h later. On the contrary, in LH patients, a decrease in the serum VEGF and b-FGF concentrations was detected after surgery and their increase afterwards. IL-10 was increased in both groups 6 h after operation and declined to preoperative levels 24 h afterwards. IFN-gamma enhanced in LH patients 6 h after surgery, whereas no modifications were detected in BH subjects.CONCLUSIONS:
This preliminary study shows that VEGF and b-FGF modifications, associated with alterations of cytokine secretion, are detectable in human undergoing hernioplasty, and suggests that they could somehow influence in the wound-healing process.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Mallas Quirúrgicas
/
Factor 2 de Crecimiento de Fibroblastos
/
Factor A de Crecimiento Endotelial Vascular
/
Hernia Inguinal
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Langenbecks Arch Surg
Año:
2005
Tipo del documento:
Article
País de afiliación:
Italia