Meroterpenes from the ascidian Aplidium aff. densum.

ABSTRACT

Chemical investigation of the ascidian Aplidium aff. densum collected at Masirah Island, Oman, has resulted in the isolation of five meroterpenes two new ones, methoxyconidiol (1) and didehydroconicol (2), and three related, known compounds, 3-5. The structures of 1 and 2 were determined by a combination of mass spectrometry and one- and two-dimensional high-field NMR techniques. Their biological activities against bacteria and human lymphoblastic cell lines were evaluated.