Pre-mRNA trans-splicing: from kinetoplastids to mammals, an easy language for life diversity.
Mem Inst Oswaldo Cruz
; 100(5): 501-13, 2005 Aug.
Article
en En
| MEDLINE
| ID: mdl-16184228
ABSTRACT
Since the discovery that genes are split into intron and exons, the studies of the mechanisms involved in splicing pointed to presence of consensus signals in an attempt to generalize the process for all living cells. However, as discussed in the present review, splicing is a theme full of variations. The trans-splicing of pre-mRNAs, the joining of exons from distinct transcripts, is one of these variations with broad distribution in the phylogenetic tree. The biological meaning of this phenomenon is discussed encompassing reactions resembling a possible noise to mechanisms of gene expression regulation. All of them however, can contribute to the generation of life diversity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Precursores del ARN
/
Kinetoplastida
/
Trans-Empalme
/
Mamíferos
/
Nematodos
Límite:
Animals
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Año:
2005
Tipo del documento:
Article
País de afiliación:
Brasil