N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands.
Bioorg Med Chem Lett
; 15(24): 5419-23, 2005 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-16213721
ABSTRACT
A series of N-8-substituted benztropinamines was synthesized and evaluated for binding at the dopamine (DAT), serotonin (SERT), norepinephrine (NET) transporters, and muscarinic M1 receptors. In general, the isosteric replacement of the C-3 benzhydrol ether of benztropine by a benzhydryl amino group was well tolerated at the DAT. However, for certain N-8 substituted derivatives, selectivity over muscarinic M1 receptor affinity was reduced.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Benzotropina
/
Proteínas de Transporte de Dopamina a través de la Membrana Plasmática
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos