Increased A-ring reduction of glucocorticoids in obese Zucker rats: effects of insulin sensitization.
Obes Res
; 13(9): 1523-6, 2005 Sep.
Article
en En
| MEDLINE
| ID: mdl-16222053
ABSTRACT
OBJECTIVE:
Obesity is associated with altered glucocorticoid metabolism, which may impact on hypothalamic-pituitary-adrenal axis activity. Here we characterize hepatic 5alpha- and 5beta-reductase in obese rats and their responses to insulin sensitization. RESEARCH METHODS AND PROCEDURES Hepatic A-ring reductase protein and mRNA were assessed in lean and obese Zucker rats after insulin sensitization with metformin or rosiglitazone (n = 7 to 8/group).RESULTS:
Hepatic 5alpha-reductase 1 and 5beta-reductase mRNA and protein (p < 0.01) were increased in obese rats. Insulin sensitization ameliorated increased 5alpha-reductase 1 mRNA in obese rats (p < 0.01) and partially reversed increased 5beta-reductase activity.DISCUSSION:
Hepatic clearance of glucocorticoids by 5alpha- and 5beta-reductase is increased in obese Zucker rats, and this increase in clearance is attenuated by insulin sensitization. This increased hepatic clearance may underpin compensatory activation of the hypothalamic-pituitary-adrenal axis in obesity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxidorreductasas
/
Colestenona 5 alfa-Reductasa
/
Glucocorticoides
/
Insulina
/
Hígado
/
Obesidad
Límite:
Animals
Idioma:
En
Revista:
Obes Res
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
FISIOLOGIA
/
METABOLISMO
Año:
2005
Tipo del documento:
Article
País de afiliación:
Reino Unido