Preclinical science regarding cannabinoids as analgesics: an overview.
Pain Res Manag
; 10 Suppl A: 7A-14A, 2005.
Article
en En
| MEDLINE
| ID: mdl-16237476
ABSTRACT
Modern pharmacology of cannabinoids began in 1964 with the isolation and partial synthesis of delta-9-tetrahydrocannabinol, the main psycho-active agent in herbal cannabis. Since then, potent antinociceptive and antihyperalgesic effects of cannabinoid agonists in animal models of acute and chronic pain; the presence of cannabinoid receptors in pain-processing areas of the brain, spinal cord and periphery; and evidence supporting endogenous modulation of pain systems by cannabinoids has provided support that cannabinoids exhibit significant potential as analgesics. The present article presents an overview of the preclinical science.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Cannabinoides
/
Analgésicos
Límite:
Animals
Idioma:
En
Revista:
Pain Res Manag
Asunto de la revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Año:
2005
Tipo del documento:
Article