A randomized trial assessing the utility of a test-dose program with taxanes.
Curr Med Res Opin
; 21(10): 1611-6, 2005 Oct.
Article
en En
| MEDLINE
| ID: mdl-16238901
ABSTRACT
OBJECTIVE:
Taxanes are commonly used anticancer agents with a potential of producing an allergic or hypersensitivity reaction (HSR). We performed a randomized study to evaluate the value of a test dose given prior to the full dose of either paclitaxel or docetaxel. RESEARCH DESIGN ANDMETHODS:
Patients were randomly assigned to either the administration of the full dose or to the prior administration of a 1 mg intravenous test dose of either paclitaxel or docetaxel. The primary endpoints were severity of the HSR and the cost of drug wastage due to a HSR.RESULTS:
Two hundred and eighteen patients were randomized from three different treatment sites. The overall incidence of HSR was 6.5% and there was no significant difference in the incidence of HSR in either group. The mean HSR severity grade was 2.8 for patients without a test dose and 2.3 for those receiving a test dose. There was, however, a reduction in the wastage of taxane in the test dose arm. Wastage avoided in the test dose arm was $1573 per patient who had a HSR and $104 per patient treated with a taxane.CONCLUSION:
Although a test dose may not reduce the severity of a HSR with the administration of a taxane, it does reduce the cost associated with drug wastage.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Taxoides
/
Antineoplásicos Fitogénicos
Tipo de estudio:
Clinical_trials
/
Etiology_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Curr Med Res Opin
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos