Substituted phenanthrenes with basic amino side chains: a new series of anti-breast cancer agents.

Srivastava, Ajay Kumar; Sharma, Ramesh; Mishra, Rajeev; Balapure, Anil Kumar; Murthy, Puvvada S R; Panda, Gautam

Srivastava, Ajay Kumar; Sharma, Ramesh; Mishra, Rajeev; Balapure, Anil Kumar; Murthy, Puvvada S R; Panda, Gautam.

Afiliación

Shagufta; Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, UP, India.

Bioorg Med Chem ; 14(5): 1497-505, 2006 Mar 01.

Article en En | MEDLINE | ID: mdl-16249093

ABSTRACT

ABSTRACT

In the course of our search for new anti-breast cancer agents, substituted phenanthrenes with basic amino side chains were synthesized and some of them showed remarkable antiproliferative activity against ER +ve MCF-7 cell line with IC(50) in the range of 3.53-22.25 microM. One of the compounds 15 ca showed anti-breast cancer activity in 7,12-dimethylbenz[a]anthracene (DMBA) induced hormone-dependent mammary tumor in rat and the activity was comparable to that shown by tamoxifen.

Asunto(s)

Antineoplásicos/farmacología; Neoplasias de la Mama/patología; Neoplasias Mamarias Experimentales/tratamiento farmacológico; Fenantrenos/farmacología; 9,10-Dimetil-1,2-benzantraceno/farmacología; Aminoácidos/química; Animales; Línea Celular Tumoral; Concentración 50 Inhibidora; Neoplasias Mamarias Experimentales/inducido químicamente; Modelos Químicos; Fenantrenos/síntesis química; Ratas; Tamoxifeno/farmacología; Factores de Tiempo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenantrenos / Neoplasias de la Mama / Neoplasias Mamarias Experimentales / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2006 Tipo del documento: Article País de afiliación: India

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