Effects of ganoderma lucidum extract on chemotherapy-induced nausea and vomiting in a rat model.
Am J Chin Med
; 33(5): 807-15, 2005.
Article
en En
| MEDLINE
| ID: mdl-16265993
ABSTRACT
Chemotherapy is highly cytotoxic, causing a number of severe adverse effects such as nausea and vomiting. Herbal medicines, which can often be used on a daily basis for prolonged treatment, may be clinically beneficial. Ganoderma lucidum or Lingzhi mushroom has been recognized as a remedy in treating a number of medical conditions, including balancing immunity and decreasing drug-induced side effects. It has been shown that rats react to emetic stimuli, like the chemotherapy agent cisplatin, by increased consumption of kaolin, known as pica; and this rat model has been utilized to evaluate novel anti-emetic compounds. In this study, we evaluated the effects of a G. lucidum extract (SunRecome, the most commonly used Lingzhi mushroom extract in China) in attenuating cisplatin-induced nausea and vomiting in the rat pica model. We observed that intraperitoneal cisplatin injection caused a significant increase in kaolin intake at 24, 48, 72 and 96 hours, reflecting cisplatin's nausea and vomiting action. This cisplatin-induced kaolin intake dose-dependently decreased after 1, 3 and 10 mg/kg G. lucidum extract injection (p < 0.01). In addition, there was a significant reduction of food intake after cisplatin. The cisplatin-induced food intake reduction improved significantly after G. lucidum extract administrations in a dose-related manner (p < 0.01), suggesting a supportive effect of the extract on general body condition. Future controlled clinical trials are needed to evaluate the safety and effectiveness of this herbal medication.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vómitos
/
Medicamentos Herbarios Chinos
/
Cisplatino
/
Reishi
/
Náusea
Límite:
Animals
Idioma:
En
Revista:
Am J Chin Med
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos