One-year post-transplant weight gain is a risk factor for graft loss.
Am J Transplant
; 5(12): 2922-8, 2005 Dec.
Article
en En
| MEDLINE
| ID: mdl-16303006
ABSTRACT
Metabolic syndrome (MS) and obesity participate in the pathogenesis of kidney disease. We explored the impact of MS and post-transplant weight gain on graft survival. Two hundred ninety-two renal transplant recipients (RTRs) were included in the study. Various parameters (e.g. anthropometric, biological) were measured at the time of transplantation as well as 1 year post-transplant. The proportion of patients with overweight or obesity significantly increased during the first year post-transplant (p = 0.04). Mean weight gain was 2.7 +/- 5.8 kg. Thirty patients (10.3%) lost their graft during follow-up. In multivariate analysis, patients with an increase in body mass index (BMI) of more than 5% at 1 year post-transplant had an increased risk of graft loss with (HR 2.82 [95% CI 1.11-7.44], p = 0.015) or without death censoring (HR 2.31 [95% CI 1.06-5.04], p = 0.035). Low creatinine clearance (HR 4.72 [95% CI 1.63-13.69], p = 0.004), high urinary protein excretion (HR 3.21 [95% CI 1.27-8.18], p = 0.014) and delayed graft function (DGF) (HR 2.621 [95% CI 1.07-6.39], p = 0.036) were also independent risk factors for graft loss. MS did not independently predict graft loss, partly due to significant interactions with low-grade inflammation. We conclude that post-transplant weight gain significantly reduces graft survival.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aumento de Peso
/
Trasplante de Riñón
/
Síndrome Metabólico
/
Nefropatías Diabéticas
/
Supervivencia de Injerto
/
Obesidad
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Transplant
Asunto de la revista:
TRANSPLANTE
Año:
2005
Tipo del documento:
Article
País de afiliación:
Francia