Cooperative type of platelet hypersensitivity to ADP.

Shabanova, E Yu; Mindukshev, I V; Malakhovskaya, E A; Vivulanets, E V; Petrishchev, N N; Krivchenko, A I

Shabanova, E Yu; Mindukshev, I V; Malakhovskaya, E A; Vivulanets, E V; Petrishchev, N N; Krivchenko, A I.

Afiliación

Shabanova EY; Laboratory for Physiology of Respiration, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg. helen_shabanova@mail.ru

Bull Exp Biol Med ; 140(3): 282-4, 2005 Sep.

Article en En | MEDLINE | ID: mdl-16307036

RESUMEN

We found that gestosis is associated with platelet hypersensitivity to ADP. Cell P2X1 receptors exhibited a positive cooperative response to ADP (EC(50)=10.88+/-3.70 nM, Hill constant n=2.59+/-0.50 rel. units). Cooperative binding of ADP to platelet P2X1 receptors was also observed during incubation of cells from pregnant women with isosorbide dinitrate.

Asunto(s)

Adenosina Difosfato/farmacología; Agregación Plaquetaria/efectos de los fármacos; Preeclampsia/sangre; Femenino; Humanos; Embarazo; Receptores Purinérgicos P2/fisiología; Receptores Purinérgicos P2X

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Adenosina Difosfato / Agregación Plaquetaria Límite: Female / Humans / Pregnancy Idioma: En Revista: Bull Exp Biol Med Año: 2005 Tipo del documento: Article Pais de publicación: Estados Unidos

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