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Increased survival of tumor-bearing mice by the delta opioid SNC 80.
Gomez-Flores, Ricardo; Caballero-Hernández, Diana; Tamez-Guerra, Reyes; Rodríguez-Padilla, Cristina; Tamez-Guerra, Patricia; Rice, Kenner C; Hicks, Mary E; Weber, Richard J.
Afiliación
  • Gomez-Flores R; Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, NL, México. rgomez60@hotmail.com
Anticancer Res ; 25(6C): 4563-7, 2005.
Article en En | MEDLINE | ID: mdl-16334142
Opioids represent a major source of relief from pain. However, opioid abuse may cause immunosuppression and cancer. We have recently reported results on novel non-peptidic delta- and mu-selective opioids that induced immunopotentiation of T cell and macrophage functions in vitro and ex vivo. In the present study, the effects of the delta-opioid receptor agonist and potent analgesic (+)-4-((alpha R)-alpha-((2S, 5R)-4-allyl-2, 5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N, N-diethyl-benzamide (SNC80) on in vitro and in vivo tumor cell growth were investigated using the L5178Y-R murine model. SNC80 marginally, but significantly (p < 0.05), inhibited (up to 14%) the in vitro growth of L5178Y-R tumor cells. However, in vivo intratumor administration of SNC80 (2 and 4 mg/kg) reduced up to 60% L5178Y-R tumor-bearing Balb/c mice death, and significantly (p < 0.05) reduced tumor weights (up to 73% reduction) in these animals. This study may support the evaluation of SNC80 in preclinical and clinical studies.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas / Benzamidas / Linfoma Límite: Animals Idioma: En Revista: Anticancer Res Año: 2005 Tipo del documento: Article Pais de publicación: Grecia
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas / Benzamidas / Linfoma Límite: Animals Idioma: En Revista: Anticancer Res Año: 2005 Tipo del documento: Article Pais de publicación: Grecia