Altered response to rTMS in patients with Alzheimer's disease.
Clin Neurophysiol
; 117(1): 103-9, 2006 Jan.
Article
en En
| MEDLINE
| ID: mdl-16364684
ABSTRACT
OBJECTIVE:
In this study, we tested the excitability of cortical motor areas in patients with Alzheimer's disease. Because repetitive transcranial magnetic stimulation (rTMS) modulates cortical excitability, possibly by inducing a short-term increase in synaptic efficacy, we used rTMS to investigate motor cortex excitability in patients with Alzheimer's disease.METHODS:
We tested the changes in the size and threshold of motor evoked potential (MEP) and cortical silent period (CSP) duration evoked by focal rTMS delivered in 10 trains of 10 stimuli at 5Hz frequency and 120% rMth intensity in a group of patients with Alzheimer's disease, and age-matched controls. In a further session, rTMS was also delivered at 1Hz frequency (trains of 10 stimuli, 120% rMth).RESULTS:
Whereas in control subjects, 5Hz-rTMS elicited normal MEPs that progressively increased in size during the train, in patients, it elicited MEPs that decreased in size. The increase in the duration of the CSP was similar in patients and healthy controls. One hertz rTMS left the MEP amplitude unchanged in patients and healthy controls.CONCLUSIONS:
The lack of MEP facilitation reflects an altered response to 5Hz-rTMS in patients with Alzheimer's disease.SIGNIFICANCE:
Our rTMS findings strongly suggest an altered cortical plasticity in excitatory circuits within motor cortex in patients with Alzheimer's disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Potenciales Evocados Motores
/
Estimulación Magnética Transcraneal
/
Enfermedad de Alzheimer
/
Corteza Motora
Tipo de estudio:
Observational_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Neurophysiol
Asunto de la revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Italia